Peripheral Circulation and Astrocytes Contribute to the MSC-Mediated Increase in IGF-1 Levels in the Infarct Cortex in a dMCAO Rat Model

• Main Authors: Xiaobo Li (Author), Wenxiu Yu (Author), Yunqian Guan (Author), Haiqiang Zou (Author), Zhaohui Liang (Author), Min Huang (Author), Renchao Zhao (Author), Chunsong Zhao (Author), Zhenhua Ren (Author), Zhiguo Chen (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and Purpose. Previously, we found that insulin-like growth factor-1 (IGF-1) levels in the infarct cortex in the acute phase of distal middle cerebral artery occlusion (dMCAO) rats are increased by intravenous infusion of allogeneic mesenchymal stem/stromal cells (MSCs). CD68+ microglia an...