Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593

• Main Authors: Asher L. Brandt (Author), Sumanta Garai (Author), Ayat Zagzoog (Author), Dow P. Hurst (Author), Lesley A. Stevenson (Author), Roger G. Pertwee (Author), Gregory H. Imler (Author), Patricia H. Reggio (Author), Ganesh A. Thakur (Author), Robert B. Laprairie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Positive allosteric modulation of the type 1 cannabinoid receptor (CB1R) has substantial potential to treat both neurological and immune disorders. To date, a few studies have evaluated the structure-activity relationship (SAR) for CB1R positive allosteric modulators (PAMs). In this study, we separa...