Antithrombotic Effect of shRNA Target F12 Mediated by Adeno-Associated Virus

• Main Authors: Fanfan Li (Author), Xiao Yang (Author), Jie Liu (Author), Kuangyi Shu (Author), Chenfang Shen (Author), Tao Chen (Author), Wei Yang (Author), Shanshan Li (Author), Xiaoou Wang (Author), Minghua Jiang (Author)
• Format: Book
• Published: Elsevier, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Coagulation factor XII (FXII) plays a crucial role in thrombosis. Moreover, deficiencies in FXII are not associated with excessive bleeding, and its depletion exhibits satisfactory protective effect on thrombus formation. Several strategies targeting FXII have been applied to inhibit thrombosis form...