Analysis of cellularity in H&E-stained rat bone marrow tissue via deep learning

• Main Authors: Smadar Shiffman (Author), Edgar A. Rios Piedra (Author), Adeyemi O. Adedeji (Author), Catherine F. Ruff (Author), Rachel N. Andrews (Author), Paula Katavolos (Author), Evan Liu (Author), Ashley Forster (Author), Jochen Brumm (Author), Reina N. Fuji (Author), Ruth Sullivan (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Our objective was to develop an automated deep-learning-based method to evaluate cellularity in rat bone marrow hematoxylin and eosin whole slide images for preclinical safety assessment. We trained a shallow CNN for segmenting marrow, 2 Mask R-CNN models for segmenting megakaryocytes (MKCs), and sm...