IRE1α regulates ROS and immune responses after UVB irradiation

• Main Authors: Jeongin Son (Author), Jacob T Bailey (Author), Stephen Worrell (Author), Adam B Glick (Author)
• Format: Book
• Published: Bioscientifica, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: UV irradiation of the skin induces photo damage and generates cytotoxic intracellular reactive oxygen species (ROS), activating the unfolded protein response (UPR) to adapt or reduce these UVB-mediated damages. This study was designed to understand the role of the UPR mediator IRE1α in th...