Emetine Di-HCl Attenuates Type 1 Diabetes Mellitus in Mice

• Main Authors: LaQueta K Hudson (Author), Meghan E Dancho (Author), Jianhua Li (Author), Johanna B Bruchfeld (Author), Ahmed A Ragab (Author), Mingzhu M He (Author), Meaghan Bragg (Author), Delaney Lenaghan (Author), Michael D Quinn (Author), Jason R Fritz (Author), Matthew V Tanzi (Author), Harold A Silverman (Author), William M Hanes (Author), Yaakov A Levine (Author), Valentin A Pavlov (Author), Peder S Olofsson (Author), Jesse Roth (Author), Yousef Al-Abed (Author), Ulf Andersson (Author), Kevin J Tracey (Author), Sangeeta S Chavan (Author)
• Format: Book
• Published: BMC, 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease characterized by β cell destruction, insulin deficiency and hyperglycemia. Activated macrophages and autoimmune T cells play a crucial role in the pathogenesis of hyperglycemia in NOD murine diabetes models, but the molecular me...