2‐Deoxyglucose and hydroxychloroquine HPLC‐MS-MS analytical methods and pharmacokinetic interactions after oral co‐administration in male rats

2‐Deoxyglucose and hydroxychloroquine HPLC‐MS-MS analytical methods and pharmacokinetic interactions after oral co‐administration in male rats

Abstract Our previous work has shown a synergistic tumoricidal efficacy of combining the hexokinase (HK) inhibitor 2‐deoxyglucose (2‐DG) and the autophagy inhibitor chloroquine (CQ) through intraperitoneal injections on HK2‐addicted prostate cancers in animal models. The pharmacokinetic (PK) behavio...

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Main Authors: Dongxiao Sun (Author), Sangyub Kim (Author), Deepkamal Karelia (Author), Yibin Deng (Author), Cheng Jiang (Author), Junxuan Lü (Author)
Format: Book
Published: Wiley, 2024-02-01T00:00:00Z.
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