Discovery of new quinolines as potent colchicine binding site inhibitors: design, synthesis, docking studies, and anti-proliferative evaluation

• Main Authors: Mohamed Hagras (Author), Moshira A. El Deeb (Author), Heba S. A. Elzahabi (Author), Eslam B. Elkaeed (Author), Ahmed B. M. Mehany (Author), Ibrahim H. Eissa (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Discovering of new anticancer agents with potential activity against tubulin polymerisation is still a promising approach. Colchicine binding site inhibitors are the most relevant anti-tubulin polymerisation agents. Thus, new quinoline derivatives have been designed and synthesised to possess the sa...