Kaurenoic Acid Reduces Ongoing Chronic Constriction Injury-Induced Neuropathic Pain: Nitric Oxide Silencing of Dorsal Root Ganglia Neurons

• Main Authors: Tiago H. Zaninelli (Author), Sandra S. Mizokami (Author), Mariana M. Bertozzi (Author), Telma Saraiva-Santos (Author), Felipe A. Pinho-Ribeiro (Author), Gabriele Inácio de Oliveira (Author), Renata Streck (Author), Eduardo J. A. Araújo (Author), Nilton S. Arakawa (Author), Sergio M. Borghi (Author), Rubia Casagrande (Author), Waldiceu A. Verri (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Kaurenoic acid (KA) is a diterpene extracted from <i>Sphagneticola trilobata</i> (L.) Pruski. KA presents analgesic properties. However, the analgesic activity and mechanisms of action of KA in neuropathic pain have not been investigated so far; thus, we addressed these points in the pre...