Exposure-Response and Clinical Outcome Modeling of Inhaled Budesonide/Formoterol Combination in Asthma Patients

• Main Authors: Hyun-moon Back (Author), Jong Bong Lee (Author), Anhye Kim (Author), Seon-Jong Park (Author), Junyeong Kim (Author), Jung-woo Chae (Author), Seung Soo Sheen (Author), Leonid Kagan (Author), Hae-Sim Park (Author), Young-Min Ye (Author), Hwi-yeol Yun (Author)
• Format: Book
• Published: MDPI AG, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Exposure-response and clinical outcome (CO) model for inhaled budesonide/formoterol was developed to quantify the relationship among pharmacokinetics (PK), pharmacodynamics (PD) and CO of the drugs and evaluate the covariate effect on model parameters. Sputum eosinophils cationic proteins (ECP) and...