Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier

• Main Authors: Kim A Lennox (Author), Richard Owczarzy (Author), Derek M Thomas (Author), Joseph A Walder (Author), Mark A Behlke (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Anti-microRNA oligonucleotides (AMOs) are steric blocking antisense reagents that inhibit microRNA (miRNA) function by hybridizing and repressing the activity of a mature miRNA. First generation AMOs employed 2'-O-Methyl RNA nucleotides (2'OMe) with phosphorothioate (PS) internucleotide li...