Mitochondrial Iron Overload-Mediated Inhibition of Nrf2-HO-1/GPX4 Assisted ALI-Induced Nephrotoxicity

• Main Authors: Hui-Fang Deng (Author), Lan-Xin Yue (Author), Ning-Ning Wang (Author), Yong-Qiang Zhou (Author), Wei Zhou (Author), Xian Liu (Author), Yu-Hao Ni (Author), Cong-Shu Huang (Author), Li-Zhen Qiu (Author), Hong Liu (Author), Hong-Ling Tan (Author), Xiang-Lin Tang (Author), Yu-Guang Wang (Author), Zeng-Chun Ma (Author), Yue Gao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aristolactam I (ALI) is an active component derived from some Traditional Chinese medicines (TCMs), and also the important metabolite of aristolochic acid. Long-term administration of medicine-containing ALI was reported to be related to aristolochic acid nephropathy (AAN), which was attributed to A...