Pulsatile Chronotherapeutic Drug Delivery for Controlling Early Morning Surge in Blood Pressure; Effect of Coating on Eplerenone In-vitro, In-vivo Release and Urinary Na/K Ratio

• المؤلفون الرئيسيون: Maha Abd El hameed Marzouk (مؤلف), Manal Kamal Darwish (مؤلف), Ghada Ehab Yassin (مؤلف), Marwa Adel Abd El-Fattah (مؤلف)
• التنسيق: كتاب
• منشور في: Universidade de São Paulo, 2022-05-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abstract The objective of the present study was to develop time delayed chronotherapeutic formulation of Eplerenone (Ep) to provide rapid drug release after a pre-determined lag time for the treatment of early morning hypertension. Cyclodextrin complexation was used to prepare fast release Ep core t...