The Immunomodulatory Role of Adjuvants in Vaccines Formulated with the Recombinant Antigens Ov-103 and Ov-RAL-2 against Onchocerca volvulus in Mice.

• Main Authors: Jessica A Hess (Author), Bin Zhan (Author), April R Torigian (Author), John B Patton (Author), Nikolai Petrovsky (Author), Tingting Zhan (Author), Maria Elena Bottazzi (Author), Peter J Hotez (Author), Thomas R Klei (Author), Sara Lustigman (Author), David Abraham (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:In some regions in Africa, elimination of onchocerciasis may be possible with mass drug administration, although there is concern based on several factors that onchocerciasis cannot be eliminated solely through this approach. A vaccine against Onchocerca volvulus would provide a critical...