Hepatic Ischemia-Reperfusion Impairs Blood-Brain Barrier Partly Due to Release of Arginase From Injured Liver

• Main Authors: Liang Zhu (Author), Han Zhou (Author), Feng Xu (Author), Hanyu Yang (Author), Ping Li (Author), Yun Sheng (Author), Peihua Liu (Author), Weimin Kong (Author), Xiaonan Liu (Author), Lu Yang (Author), Li Liu (Author), Xiaodong Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: Hepatic ischemia-reperfusion (HIR) induces remote organs injury, including the brain. The homeostasis of the brain is maintained by the blood-brain barrier (BBB); thus, we aimed to investigate whether HIR impaired BBB and attempted to elucidate its underlying mechanism.Methods: Cell viability o...