Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors

• Главные авторы: Ibrahim M. Salem (Автор), Samia M. Mostafa (Автор), Ismail Salama (Автор), Osama I. El-Sabbagh (Автор), Wael A. H. Hegazy (Автор), Tarek S. Ibrahim (Автор)
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• Опубликовано: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Предметы: article
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The present study aimed to investigate the antitumor effect of simultaneous inhibition of dihydrofolate reductase (DHFR) enzyme. We designed some novel pyrazolo[3,4-d]pyrimidines bearing different amino acid conjugates as efficient antifolate agents attributable to their structural similarity with m...