Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors

• Autores principales: Ibrahim M. Salem (Autor), Samia M. Mostafa (Autor), Ismail Salama (Autor), Osama I. El-Sabbagh (Autor), Wael A. H. Hegazy (Autor), Tarek S. Ibrahim (Autor)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

The present study aimed to investigate the antitumor effect of simultaneous inhibition of dihydrofolate reductase (DHFR) enzyme. We designed some novel pyrazolo[3,4-d]pyrimidines bearing different amino acid conjugates as efficient antifolate agents attributable to their structural similarity with m...