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Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors

The present study aimed to investigate the antitumor effect of simultaneous inhibition of dihydrofolate reductase (DHFR) enzyme. We designed some novel pyrazolo[3,4-d]pyrimidines bearing different amino acid conjugates as efficient antifolate agents attributable to their structural similarity with m...

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Bibliographic Details
Main Authors:	Ibrahim M. Salem (Author), Samia M. Mostafa (Author), Ismail Salama (Author), Osama I. El-Sabbagh (Author), Wael A. H. Hegazy (Author), Tarek S. Ibrahim (Author)
Format:	Book
Published:	Taylor & Francis Group, 2023-12-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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