Novel Anti-Trop2 Nanobodies Disrupt Receptor Dimerization and Inhibit Tumor Cell Growth

• Main Authors: Junwen Deng (Author), Zhongmin Geng (Author), Linli Luan (Author), Dingwen Jiang (Author), Jian Lu (Author), Hanzhong Zhang (Author), Bingguan Chen (Author), Xinlin Liu (Author), Dongming Xing (Author)
• Format: Book
• Published: MDPI AG, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<b>Background:</b> Trop2 (trophoblast cell-surface antigen 2) is overexpressed in multiple malignancies and is closely associated with poor prognosis, thus positioning it as a promising target for pan-cancer therapies. Despite the approval of Trop2-targeted antibody-drug conjugates (ADCs...