Zinc binding groups for histone deacetylase inhibitors

Zinc binding groups (ZBGs) play a crucial role in targeting histone deacetylase inhibitors (HDACIs) to the active site of histone deacetylases (HDACs), thus determining the potency of HDACIs. Due to the high affinity to the zinc ion, hydroxamic acid is the most commonly used ZBG in the structure of...

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Main Authors: Lei Zhang (Author), Jian Zhang (Author), Qixiao Jiang (Author), Li Zhang (Author), Weiguo Song (Author)
Format: Book
Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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