Aptamer-Gemcitabine Conjugates with Enzymatically Cleavable Linker for Targeted Delivery and Intracellular Drug Release in Cancer Cells

• Main Authors: Jianjun Qi (Author), Zihua Zeng (Author), Zhenghu Chen (Author), Cole Nipper (Author), Xiaohui Liu (Author), Quanyuan Wan (Author), Jian Chen (Author), Ching-Hsuan Tung (Author), Youli Zu (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gemcitabine is a chemotherapeutic used clinically to treat a variety of cancers. However, because it lacks tumor cell specificity, gemcitabine may cause off-target cytotoxicity and adversely impact patients. To impart cancer cell specificity to gemcitabine and improve its therapeutic efficacy, we sy...