Aptamer-Gemcitabine Conjugates with Enzymatically Cleavable Linker for Targeted Delivery and Intracellular Drug Release in Cancer Cells

• Prif Awduron: Jianjun Qi (Awdur), Zihua Zeng (Awdur), Zhenghu Chen (Awdur), Cole Nipper (Awdur), Xiaohui Liu (Awdur), Quanyuan Wan (Awdur), Jian Chen (Awdur), Ching-Hsuan Tung (Awdur), Youli Zu (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2022-04-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Gemcitabine is a chemotherapeutic used clinically to treat a variety of cancers. However, because it lacks tumor cell specificity, gemcitabine may cause off-target cytotoxicity and adversely impact patients. To impart cancer cell specificity to gemcitabine and improve its therapeutic efficacy, we sy...