Aptamer-Gemcitabine Conjugates with Enzymatically Cleavable Linker for Targeted Delivery and Intracellular Drug Release in Cancer Cells

• 主要な著者: Jianjun Qi (著者), Zihua Zeng (著者), Zhenghu Chen (著者), Cole Nipper (著者), Xiaohui Liu (著者), Quanyuan Wan (著者), Jian Chen (著者), Ching-Hsuan Tung (著者), Youli Zu (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2022-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Gemcitabine is a chemotherapeutic used clinically to treat a variety of cancers. However, because it lacks tumor cell specificity, gemcitabine may cause off-target cytotoxicity and adversely impact patients. To impart cancer cell specificity to gemcitabine and improve its therapeutic efficacy, we sy...