Negative Relationship Between Morphine Analgesia and P-Glycoprotein Expression Levels in the Brain

• Main Authors: Wakako Hamabe (Author), Takehiko Maeda (Author), Norikazu Kiguchi (Author), Chizuko Yamamoto (Author), Shogo Tokuyama (Author), Shiroh Kishioka (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

It is known that opioid analgesics given systemically have limited distribution into the brain because of their interaction with P-glycoprotein (P-gp), an ATP-dependent efflux pump acting at the blood-brain barrier (BBB). We previously found that morphine and fentanyl showed higher analgesic potenci...