Negative Relationship Between Morphine Analgesia and P-Glycoprotein Expression Levels in the Brain
It is known that opioid analgesics given systemically have limited distribution into the brain because of their interaction with P-glycoprotein (P-gp), an ATP-dependent efflux pump acting at the blood-brain barrier (BBB). We previously found that morphine and fentanyl showed higher analgesic potenci...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2007-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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