Targeted Delivery of Auristatin-Modified Toxins to Pancreatic Cancer Using Aptamers

• Egile Nagusiak: Christina Kratschmer (Egilea), Matthew Levy (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2018-03-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Pancreatic cancer is one of the most lethal malignancies. Treatment with the first-line agent, gemcitabine, is often unsuccessful because it, like other traditional chemotherapeutic agents, is non-specific, resulting in off-target effects that necessitate administration of subcurative doses. Alterna...