Anaphylatoxins orchestrate Th17 response via interactions between CD16+ monocytes and pleural mesothelial cells in tuberculous pleural effusion.

• Main Authors: Shuanglinzi Deng (Author), Xinyue Hu (Author), Lisha Luo (Author), Wei Tang (Author), Yuanyuan Jiang (Author), Feifei Yin (Author), Chengping Hu (Author), Juntao Feng (Author), Xiaozhao Li (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The complement system is activated in tuberculous pleural effusion (TPE), with increased levels of the anaphylatoxins stimulating pleural mesothelial cells (PMCs) to secrete chemokines, which recruit nonclassical monocytes to the pleural cavity. The differentiation and recruitment of naive CD4+ T ce...