Recent advances in IAP-based PROTACs (SNIPERs) as potential therapeutic agents

• Main Authors: Chao Wang (Author), Yujing Zhang (Author), Lingyu Shi (Author), Shanbo Yang (Author), Jing Chang (Author), Yingjie Zhong (Author), Qian Li (Author), Dongming Xing (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Proteolytic targeting chimaeras (PROTACs) have been developed as an effective technology for targeted protein degradation. PROTACs are heterobifunctional molecules that can trigger the polyubiquitination of proteins of interest (POIs) by recruiting the ubiquitin-proteasome system, thereby inhibiting...