Mutational analysis of the <it>PITX2 </it>coding region revealed no common cause for transposition of the great arteries (dTGA)

• Main Authors: Goldmuntz Elizabeth (Author), Rüdiger Heinz-Juergen (Author), Schön Karin (Author), Roeth Ralph (Author), Niesler Beate (Author), Muncke Nadja (Author), Goodship Judith (Author), Rappold Gudrun (Author)
• Format: Book
• Published: BMC, 2005-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>PITX2 is a bicoid-related homeodomain transcription factor that plays an important role in asymmetric cardiogenesis. Loss of function experiments in mice cause severe heart malformations, including transposition of the great arteries...