Analgesic effect of GT-0198, a structurally novel glycine transporter 2 inhibitor, in a mouse model of neuropathic pain

• Main Authors: Yu Omori (Author), Mayumi Nakajima (Author), Kazumi Nishimura (Author), Eiki Takahashi (Author), Tadamasa Arai (Author), Masato Akahira (Author), Tomohiko Suzuki (Author), Mie Kainoh (Author)
• Format: Book
• Published: Elsevier, 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study was conducted to identify the characteristic pharmacological features of GT-0198 that is phenoxymethylbenzamide derivatives. GT-0198 inhibited the function of glycine transporter 2 (GlyT2) in human GlyT2-expressing HEK293 cells and did not bind various major transporters or receptors of n...