Dysregulation of Toll-Like Receptor Signaling-Associated Gene Expression in X-Linked Agammaglobulinemia: Implications for Correlations Genotype-Phenotype and Disease Expression

• Үндсэн зохиолчид: Marcelo Teocchi (Зохиогч), Thaís de Andrade Eugênio (Зохиогч), Lia Furlaneto Marega (Зохиогч), Isabella Quinti (Зохиогч), Maria Marluce dos Santos Vilela (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Karger Publishers, 2024-08-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Introduction: In X-linked agammaglobulinemia (XLA), the diversity of BTK variants complicates the study of genotype-phenotype correlations. Since BTK negatively regulates toll-like receptors (TLRs), we investigated if distinct BTK mutation types selectively modulate TLR pathways, affecting disease e...