Dysregulation of Toll-Like Receptor Signaling-Associated Gene Expression in X-Linked Agammaglobulinemia: Implications for Correlations Genotype-Phenotype and Disease Expression

• Główni autorzy: Marcelo Teocchi (Autor), Thaís de Andrade Eugênio (Autor), Lia Furlaneto Marega (Autor), Isabella Quinti (Autor), Maria Marluce dos Santos Vilela (Autor)
• Format: Książka
• Wydane: Karger Publishers, 2024-08-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Introduction: In X-linked agammaglobulinemia (XLA), the diversity of BTK variants complicates the study of genotype-phenotype correlations. Since BTK negatively regulates toll-like receptors (TLRs), we investigated if distinct BTK mutation types selectively modulate TLR pathways, affecting disease e...