Curcumin-Piperlongumine Hybrids with a Multitarget Profile Elicit Neuroprotection in In Vitro Models of Oxidative Stress and Hyperphosphorylation

• Main Authors: Ángel Cores (Author), Noelia Carmona-Zafra (Author), Olmo Martín-Cámara (Author), Juan Domingo Sánchez (Author), Pablo Duarte (Author), Mercedes Villacampa (Author), Paloma Bermejo-Bescós (Author), Sagrario Martín-Aragón (Author), Rafael León (Author), J. Carlos Menéndez (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Curcumin shows a broad spectrum of activities of relevance in the treatment of Alzheimer's disease (AD); however, it is poorly absorbed and is also chemically and metabolically unstable, leading to a very low oral bioavailability. A small library of hybrid compounds designed as curcumin analogu...