4-Hydroxyisoleucine inhibits tumor growth by triggering endoplasmic reticulum stress and autophagy

• Main Authors: Peng Li (Author), Yonghui Yang (Author), Lu Qiu (Author), Guangming Wan (Author), Baomei Yuan (Author), Yahong Wu (Author), Yanfeng Gao (Author), Guodong Li (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

4-Hydroxyisoleucine（4-HIL）is a non-protein amino acid that is able to reduce obesity and improve insulin sensitivity in mice, and recently emerged as a drug candidate against hypoglycemia. For the first time, we found that 4-HIL exhibits a potent anti-tumor activity in various cancer cell lines in v...