4-Hydroxyisoleucine inhibits tumor growth by triggering endoplasmic reticulum stress and autophagy

• Główni autorzy: Peng Li (Autor), Yonghui Yang (Autor), Lu Qiu (Autor), Guangming Wan (Autor), Baomei Yuan (Autor), Yahong Wu (Autor), Yanfeng Gao (Autor), Guodong Li (Autor)
• Format: Książka
• Wydane: Elsevier, 2022-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

4-Hydroxyisoleucine（4-HIL）is a non-protein amino acid that is able to reduce obesity and improve insulin sensitivity in mice, and recently emerged as a drug candidate against hypoglycemia. For the first time, we found that 4-HIL exhibits a potent anti-tumor activity in various cancer cell lines in v...