Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA

• Main Authors: Radu Mihaila (Author), Dipali Ruhela (Author), Edward Keough (Author), Elena Cherkaev (Author), Silvia Chang (Author), Beverly Galinski (Author), René Bartz (Author), Duncan Brown (Author), Bonnie Howell (Author), James J. Cunningham (Author)
• Format: Book
• Published: Elsevier, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lipid nanoparticles (LNPs) have been used to successfully deliver small interfering RNAs (siRNAs) to target cells in both preclinical and clinical studies and currently are the leading systems for in vivo delivery. Here, we propose the use of an ordinary differential equation (ODE)-based model as a...