Anti-Mycobacterial Evaluation of 7-Chloro-4-Aminoquinolines and Hologram Quantitative Structure-Activity Relationship (HQSAR) Modeling of Amino-Imino Tautomers

• Main Authors: Marcelle L. F. Bispo (Author), Camilo H. S. Lima (Author), Laura N. F. Cardoso (Author), André L. P. Candéa (Author), Flávio A. F. M. Bezerra (Author), Maria C. S. Lourenço (Author), Maria G. M. O. Henriques (Author), Ricardo B. Alencastro (Author), Carlos R. Kaiser (Author), Marcus V. N. Souza (Author), Magaly G. Albuquerque (Author)
• Format: Book
• Published: MDPI AG, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In an ongoing research program for the development of new anti-tuberculosis drugs, we synthesized three series (A, B, and C) of 7-chloro-4-aminoquinolines, which were evaluated in vitro against Mycobacterium tuberculosis (MTB). Now, we report the anti-MTB and cytotoxicity evaluations of a new series...