Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology

• Main Authors: Ning-Ning Yuan (Author), Cui-Zan Cai (Author), Ming-Yue Wu (Author), Qi Zhu (Author), HuanXing Su (Author), Min Li (Author), JiaoYan Ren (Author), Jie-Qiong Tan (Author), Jia-Hong Lu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by the accumulation of protein aggregates (namely Lewy bodies) in dopaminergic neurons in the substantia nigra region of the brain. Alpha-synuclein (α-syn) is the major component of Lewy bodies in PD pat...