Vanillic Acid Reduces Pain-Related Behavior in Knee Osteoarthritis Rats Through the Inhibition of NLRP3 Inflammasome-Related Synovitis

• Main Authors: Zhenyuan Ma (Author), Zhengquan Huang (Author), Li Zhang (Author), Xiaochen Li (Author), Bo Xu (Author), Yancheng Xiao (Author), Xiaoqing Shi (Author), Haosheng Zhang (Author), Taiyang Liao (Author), Peimin Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Synovitis plays an important role in knee osteoarthritis (KOA) pain. The activation of the NOD-like receptor protein 3 (NLRP3) inflammasome in fibroblast-like synoviocytes (FLSs) promotes KOA development. In this study, we aimed to investigate whether vanillic acid (VA), a monomer derive...