Vanillic Acid Reduces Pain-Related Behavior in Knee Osteoarthritis Rats Through the Inhibition of NLRP3 Inflammasome-Related Synovitis

• Principais autores: Zhenyuan Ma (Autor), Zhengquan Huang (Autor), Li Zhang (Autor), Xiaochen Li (Autor), Bo Xu (Autor), Yancheng Xiao (Autor), Xiaoqing Shi (Autor), Haosheng Zhang (Autor), Taiyang Liao (Autor), Peimin Wang (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Objectives: Synovitis plays an important role in knee osteoarthritis (KOA) pain. The activation of the NOD-like receptor protein 3 (NLRP3) inflammasome in fibroblast-like synoviocytes (FLSs) promotes KOA development. In this study, we aimed to investigate whether vanillic acid (VA), a monomer derive...