Overexpression of the endothelial protein C receptor is detrimental during pneumonia-derived gram-negative sepsis (Melioidosis).

• Main Authors: Liesbeth M Kager (Author), Marcel Schouten (Author), W Joost Wiersinga (Author), J Daan de Boer (Author), Lionel C W Lattenist (Author), Joris J T H Roelofs (Author), Joost C M Meijers (Author), Marcel Levi (Author), Arjen M Dondorp (Author), Charles T Esmon (Author), Cornelis van 't Veer (Author), Tom van der Poll (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The endothelial protein C receptor (EPCR) enhances anticoagulation by accelerating activation of protein C to activated protein C (APC) and mediates anti-inflammatory effects by facilitating APC-mediated signaling via protease activated receptor-1. We studied the role of EPCR in the host response du...