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Overexpression of the endothelial protein C receptor is detrimental during pneumonia-derived gram-negative sepsis (Melioidosis).

The endothelial protein C receptor (EPCR) enhances anticoagulation by accelerating activation of protein C to activated protein C (APC) and mediates anti-inflammatory effects by facilitating APC-mediated signaling via protease activated receptor-1. We studied the role of EPCR in the host response du...

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Main Authors: Liesbeth M Kager (Author), Marcel Schouten (Author), W Joost Wiersinga (Author), J Daan de Boer (Author), Lionel C W Lattenist (Author), Joris J T H Roelofs (Author), Joost C M Meijers (Author), Marcel Levi (Author), Arjen M Dondorp (Author), Charles T Esmon (Author), Cornelis van 't Veer (Author), Tom van der Poll (Author)
Format: Book
Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
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