Label-Free Assessment of Mannitol Accumulation Following Osmotic Blood-Brain Barrier Opening Using Chemical Exchange Saturation Transfer Magnetic Resonance Imaging

Label-Free Assessment of Mannitol Accumulation Following Osmotic Blood-Brain Barrier Opening Using Chemical Exchange Saturation Transfer Magnetic Resonance Imaging

Purpose: Mannitol is a hyperosmolar agent for reducing intracranial pressure and inducing osmotic blood-brain barrier opening (OBBBO). There is a great clinical need for a non-invasive method to optimize the safety of mannitol dosing. The aim of this study was to develop a label-free Chemical Exchan...

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Main Authors: Jing Liu (Author), Chengyan Chu (Author), Jia Zhang (Author), Chongxue Bie (Author), Lin Chen (Author), Safiya Aafreen (Author), Jiadi Xu (Author), David O. Kamson (Author), Peter C. M. van Zijl (Author), Piotr Walczak (Author), Miroslaw Janowski (Author), Guanshu Liu (Author)
Format: Book
Published: MDPI AG, 2022-11-01T00:00:00Z.
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