Advances in targeting the vacuolar proton-translocating ATPase (V-ATPase) for anti-fungal therapy

• Hoofdauteurs: Summer R. Hayek (Auteur), Samuel A. Lee (Auteur), Karlett J. Parra (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2014-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Vacuolar proton-translocating ATPase (V-ATPase) is a membrane-bound, multi-subunit enzyme that uses the energy of ATP hydrolysis to pump protons across membranes. V-ATPase activity is critical for pH homeostasis and organelle acidification as well as for generation of the membrane potential that dri...