Brain and Plasma Riluzole Pharmacokinetics: Effect of Minocycline Combination

• Main Authors: Aline Milane (Author), Lionel Tortolano (Author), Christine Fernandez (Author), Gilbert Bensimon (Author), Vincent Meininger (Author), Robert Farinotti (Author)
• Format: Book
• Published: Frontiers Media S.A., 2009-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PURPOSE: amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by the loss of motorneurons. The only drug approved is riluzole. Minocycline is an antibiotic with numerous neuroprotective properties. riluzole and minocycline were given to an animal model of ALS and had bene...