Total Phenytoin concentration is not well correlated with active free drug in critically-ill head trauma patients

• Main Authors: Kourosh Sadeghi (Author), Farin Hadi (Author), Arezoo Ahmadi (Author), Hadi Hamishehkar (Author), Mohammad-Taghi Beigmohammadi (Author), Ata Mahmoodpoor (Author), Mohammad Reza Rouini (Author), Shirin Farhudi (Author), Narjes Hendoui (Author), Atabak Najafi (Author), Mojtaba Mojtahedzadeh (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Phenytoin is an antiepileptic drug used widely for prophylaxis and treatment of seizure after neurotrauma. Phenytoin has a complex pharmacokinetics and monitoring of its serum concentrations is recommended during treatment. Total phenytoin concentration is routinely measured for monitorin...