A physiologically‐based pharmacokinetic precision dosing approach to manage dasatinib drug-drug interactions

• Glavni autori: Christina Kovar (Autor), Helena Leonie Hanae Loer (Autor), Simeon Rüdesheim (Autor), Laura Maria Fuhr (Autor), Fatima Zahra Marok (Autor), Dominik Selzer (Autor), Matthias Schwab (Autor), Thorsten Lehr (Autor)
• Format: Knjiga
• Izdano: Wiley, 2024-07-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Abstract Dasatinib, a second‐generation tyrosine kinase inhibitor, is approved for treating chronic myeloid and acute lymphoblastic leukemia. As a sensitive cytochrome P450 (CYP) 3A4 substrate and weak base with strong pH‐sensitive solubility, dasatinib is susceptible to enzyme‐mediated drug-drug in...