A physiologically‐based pharmacokinetic precision dosing approach to manage dasatinib drug-drug interactions

• Main Authors: Christina Kovar (Author), Helena Leonie Hanae Loer (Author), Simeon Rüdesheim (Author), Laura Maria Fuhr (Author), Fatima Zahra Marok (Author), Dominik Selzer (Author), Matthias Schwab (Author), Thorsten Lehr (Author)
• Format: Book
• Published: Wiley, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Dasatinib, a second‐generation tyrosine kinase inhibitor, is approved for treating chronic myeloid and acute lymphoblastic leukemia. As a sensitive cytochrome P450 (CYP) 3A4 substrate and weak base with strong pH‐sensitive solubility, dasatinib is susceptible to enzyme‐mediated drug-drug in...