Generating a Bispecific Antibody Drug Conjugate Targeting PRLR and HER2 with Improving the Internalization

• Main Authors: Hui-Fang Zong (Author), Bao-Hong Zhang (Author), Jian-Wei Zhu (Author)
• Formato: Libro
• Publicado: Georg Thieme Verlag KG, 2022-06-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Antibody drug conjugate (ADC) therapy has become one of the most promising approaches in cancer immunotherapy. The bispecific targeting could improve the specificity, affinity, and internalization of the ADC molecules. Prolactin preceptor (PRLR) and HER2 have crosstalk signaling in breast cancer, an...