Collateral-resistance to estrogen and HER-activated growth is associated with modified AKT, ERα, and cell-cycle signaling in a breast cancer model

• Main Authors: Kate M. Moore (Author), Vera Cerqueira (Author), Kenneth G. MacLeod (Author), Peter Mullen (Author), Richard L. Hayward (Author), Simon Green (Author), David J. Harrison (Author), David A. Cameron (Author), Simon P. Langdon (Author)
• Format: Book
• Published: Open Exploration Publishing Inc., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: A model of progressively endocrine-resistant breast cancer was investigated to identify changes that can occur in signaling pathways after endocrine manipulation. Methods: The MCF7 breast cancer model is sensitive to estrogens and anti-estrogens while variant lines previously derived from wild-...