Discovery of a novel chalcone derivative inhibiting CFTR chloride channel via AMPK activation and its anti-diarrheal application

• Main Authors: Chamnan Yibcharoenporn (Author), Phakawat Chusuth (Author), Chanon Jakakul (Author), Thanyada Rungrotmongkol (Author), Warinthorn Chavasiri (Author), Chatchai Muanprasat (Author)
• Format: Book
• Published: Elsevier, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Secretory diarrhea is one of the most common causes of death world-wide especially in children under 5 years old. Isoliquiritigenin (ISLQ), a plant-derived chalcone, has previously been shown to exert anti-secretory action in vitro and in vivo by inhibiting CFTR Cl− channels. However, its CFTR inhib...