Discovery of a novel chalcone derivative inhibiting CFTR chloride channel via AMPK activation and its anti-diarrheal application
Secretory diarrhea is one of the most common causes of death world-wide especially in children under 5 years old. Isoliquiritigenin (ISLQ), a plant-derived chalcone, has previously been shown to exert anti-secretory action in vitro and in vivo by inhibiting CFTR Cl− channels. However, its CFTR inhib...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2019-07-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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