Chloramphenicol Derivatives as Antibacterial and Anticancer Agents: Historic Problems and Current Solutions

• Main Authors: George P. Dinos (Author), Constantinos M. Athanassopoulos (Author), Dionissia A. Missiri (Author), Panagiota C. Giannopoulou (Author), Ioannis A. Vlachogiannis (Author), Georgios E. Papadopoulos (Author), Dionissios Papaioannou (Author), Dimitrios L. Kalpaxis (Author)
• Format: Book
• Published: MDPI AG, 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chloramphenicol (CAM) is the D-threo isomer of a small molecule, consisting of a p-nitrobenzene ring connected to a dichloroacetyl tail through a 2-amino-1,3-propanediol moiety. CAM displays a broad-spectrum bacteriostatic activity by specifically inhibiting the bacterial protein synthesis. In certa...