External Evaluation of Population Pharmacokinetics Models of Lithium in the Bipolar Population

• Main Authors: Lereclus Aurélie (Author), Boniffay Andréa (Author), Kallée Gauvind (Author), Blin Olivier (Author), Belzeaux Raoul (Author), Frédéric Dayan (Author), Benito Sylvain (Author), Guilhaumou Romain (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lithium has been used in the treatment of bipolar disorder for several decades. Treatment optimization is recommended for this drug, due to its narrow therapeutic range and a large pharmacokinetics (PK) variability. In addition to therapeutic drug monitoring, attempts have been made to predict indiv...