Exploring determinants of agonist efficacy at the CB1 cannabinoid receptor: Analogues of the synthetic cannabinoid receptor agonist EG‐018

• Main Authors: David B. Finlay (Author), Thuy Nguyen (Author), Thomas F. Gamage (Author), Shuli Chen (Author), Daniel G. Barrus (Author), Purvi R. Patel (Author), Brian F. Thomas (Author), Jenny L. Wiley (Author), Yanan Zhang (Author), Michelle Glass (Author)
• Format: Book
• Published: Wiley, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Neutral antagonists of GPCRs remain relatively rare-indeed, a large majority of GPCR antagonists are actually inverse agonists. The synthetic cannabinoid receptor agonist (SCRA) EG‐018 was recently reported as a low efficacy cannabinoid receptor agonist. Here we report a comparative charact...