Evolution of carbapenem resistance in klebsiella pneumoniae and escherichia coli carrying bla NDM−1 gene: imipenem exposure results in sustained resistance memory of strains in vitro

• Main Authors: Qiong Zhao (Author), Longhua Sha (Author), Zhaomeng Wu (Author), Lixue Meng (Author), Feixiang Yang (Author), Lingling Wu (Author), Chunfang Yu (Author), Hua Zhang (Author), Jingdan Yu (Author), Zhixiong Jin (Author)
• Format: Book
• Published: BMC, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Antibiotics exert an outstanding selective pressure on bacteria, forcing their chromosomal gene mutations and drug resistance genes to spread. The objective of this study is to evaluate the expression of the New Delhi Metallo-β-Lactamase-1 gene (bla NDM−1) in the clinical isolate...