Sorting nexin 3 exacerbates doxorubicin-induced cardiomyopathy via regulation of TFRC-dependent ferroptosis

• Main Authors: Wenjing Yu (Author), Yuehuai Hu (Author), Zhiping Liu (Author), Kaiteng Guo (Author), Dinghu Ma (Author), Mingxia Peng (Author), Yuemei Wang (Author), Jing Zhang (Author), Xiaolei Zhang (Author), Panxia Wang (Author), Jiguo Zhang (Author), Peiqing Liu (Author), Jing Lu (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The clinical utilization of doxorubicin (Dox) in various malignancies is restrained by its major adverse effect: irreversible cardiomyopathy. Extensive studies have been done to explore the prevention of Dox cardiomyopathy. Currently, ferroptosis has been shown to participate in the incidence and de...